The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …

The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the
accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression …

Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

Quantifying the flow of cerebrospinal fluid (CSF) is crucial for understanding brain waste
clearance and nutrient delivery, as well as edema in pathological conditions such as stroke …

Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

Effective treatments of neurodegenerative diseases require drugs to be actively transported
across the blood-brain barrier (BBB). However, nanoparticle drug carriers explored for this …