Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …

Experimental research has recognized the importance of cardiac fibroblast and
myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac …

Endothelial-to-mesenchymal transition (EndMT) has been shown to contribute to cardiac
fibrosis and heart failure (HF). Recent studies have demonstrated that EndMT is regulated …

Rationale: G protein–coupled receptor kinase 2 (GRK2) is an important molecule
upregulated after myocardial injury and during heart failure. Myocyte-specific GRK2 loss …

Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of
cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The …

Abstract Hypermobile Ehlers-Danlos syndrome (hEDS) is a heritable connective tissue
disorder with unknown molecular basis mainly characterized by generalized joint …

Radiation-induced heart injury is one of the major side effects of radiotherapy for thoracic
malignancies. Previous studies have shown that radiotherapy induced myocardial fibrosis …

Background Cardiac fibrosis is characterized by excessive extracellular matrix deposition
that contributes to compromised cardiac function and potentially heart failure. Disruptor of …

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder.
NAFLD, associated lipotoxicity, fibrosis, oxidative stress, and altered mitochondrial …

Prostate cancer patients who undergo radiotherapy frequently suffer from side effects
caused by radiation-induced damage to normal tissues adjacent to the tumor. Exposure of …