Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body
Metazoan replication-dependent (RD) histone genes encode the only known cellular
mRNAs that are not polyadenylated. These mRNAs end instead in a conserved stem-loop …
mRNAs that are not polyadenylated. These mRNAs end instead in a conserved stem-loop …
RNA biology of angiogenin: Current state and perspectives
Angiogenin (ANG) is a secreted ribonuclease best known for its ability to promote formation
of blood vessels. Extensive research over many years has elucidated its structure and …
of blood vessels. Extensive research over many years has elucidated its structure and …
Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2
MicroRNAs (miRs) participate in most cellular functions by posttranscriptional regulation of
gene expression albeit with little information regarding their role in ischemic preconditioning …
gene expression albeit with little information regarding their role in ischemic preconditioning …
New histone supply regulates replication fork speed and PCNA unloading
J Mejlvang, Y Feng, C Alabert, KJ Neelsen… - Journal of Cell …, 2014 - rupress.org
Correct duplication of DNA sequence and its organization into chromatin is central to
genome function and stability. However, it remains unclear how cells coordinate DNA …
genome function and stability. However, it remains unclear how cells coordinate DNA …
Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle
As the building blocks of chromatin, histones are central to establish and maintain particular
chromatin states associated with given cell fates. Importantly, histones exist as distinct …
chromatin states associated with given cell fates. Importantly, histones exist as distinct …
Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?
AG Matera, M Izaguire-Sierra, K Praveen… - Developmental cell, 2009 - cell.com
The principles of self-assembly and self-organization are major tenets of molecular and
cellular biology. Governed by these principles, the eukaryotic nucleus is composed of …
cellular biology. Governed by these principles, the eukaryotic nucleus is composed of …
Nuclear sorting of short RNA polymerase II transcripts
W Garland, TH Jensen - Molecular Cell, 2024 - cell.com
Mammalian genomes produce an abundance of short RNA. This is, to a large extent, due to
the genome-wide and spurious activity of RNA polymerase II (RNAPII). However, it is also …
the genome-wide and spurious activity of RNA polymerase II (RNAPII). However, it is also …
CDK11, a splicing-associated kinase regulating gene expression
M Hluchý, D Blazek - Trends in Cell Biology, 2024 - cell.com
The ability of a cell to properly express its genes depends on optimal transcription and
splicing. RNA polymerase II (RNAPII) transcribes protein-coding genes and produces pre …
splicing. RNA polymerase II (RNAPII) transcribes protein-coding genes and produces pre …
The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies
H Suzuki, R Abe, M Shimada, T Hirose, H Hirose… - Nature …, 2022 - nature.com
Non-polyadenylated mRNAs of replication-dependent histones (RDHs) are synthesized by
RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with …
RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with …
The abbreviated pluripotent cell cycle
K Kapinas, R Grandy, P Ghule… - Journal of cellular …, 2013 - Wiley Online Library
Human embryonic stem cells (hESCs) and induced pluripotent stem cells proliferate rapidly
and divide symmetrically producing equivalent progeny cells. In contrast, lineage committed …
and divide symmetrically producing equivalent progeny cells. In contrast, lineage committed …