Mechanisms of regulation of the chemokine-receptor network
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …
of leukocytes during normal immune function and as a key aspect of the inflammatory …
Chemokine: receptor structure, interactions, and antagonism
SJ Allen, SE Crown, TM Handel - Annu. Rev. Immunol., 2007 - annualreviews.org
Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …
inflammation, and development. Chemokines bind to G protein–coupled receptors and …
Chemerin is a novel adipokine associated with obesity and metabolic syndrome
Soluble protein hormones are key regulators of a number of metabolic processes, including
food intake and insulin sensitivity. We have used a signal sequence trap to identify genes …
food intake and insulin sensitivity. We have used a signal sequence trap to identify genes …
In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
T cells play an important role in immunity and repair and are implicated in diseases,
including blood cancers, viral infections, and inflammation, making them attractive targets for …
including blood cancers, viral infections, and inflammation, making them attractive targets for …
Cytokine signaling modulates blood-brain barrier function
W Pan, KP Stone, H Hsuchou… - Current …, 2011 - ingentaconnect.com
The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function.
The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how …
The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how …
Interferon receptor trafficking and signaling: Journey to the cross roads
N Zanin, C Viaris de Lesegno, C Lamaze… - Frontiers in …, 2021 - frontiersin.org
Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from
the outer surface to the inner compartments of the cell. Long considered as a passive means …
the outer surface to the inner compartments of the cell. Long considered as a passive means …
Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and-9
Y Ding, D Xu, G Feng, A Bushell, RJ Muschel… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Mesenchymal stem cells (MSCs) are known to be capable of suppressing
immune responses, but the molecular mechanisms involved and the therapeutic potential of …
immune responses, but the molecular mechanisms involved and the therapeutic potential of …
Structural basis of dimerization of chemokine receptors CCR5 and CXCR4
G protein-coupled receptors (GPCRs) are prominent drug targets responsible for
extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that …
extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that …
Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia
A Bürkle, M Niedermeier, A Schmitt-Gräff… - Blood, The Journal …, 2007 - ashpublications.org
CXCL13 is a homeostatic chemokine for lymphocyte homing and positioning within follicles
of secondary lymphoid tissues, acting through its cognate receptor, CXCR5. Moreover, the …
of secondary lymphoid tissues, acting through its cognate receptor, CXCR5. Moreover, the …
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review
Since the pioneering work dealing with the synthesis and physicochemical aspects of
dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and …
dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and …