Modeling flexible macromolecules is one of the foremost challenges in single-particle
cryogenic-electron microscopy (cryo-EM), with the potential to illuminate fundamental …

Macromolecules change their shape (conformation) in the process of carrying out their
functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of …

Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for
elucidating the three-dimensional (3D) structure of proteins and other biologically significant …

Protein structure determination from cryo-EM data requires reconstructing a 3D volume (or
distribution of volumes) from many noisy and randomly oriented 2D projection images. While …

Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights
into the dynamics of proteins and other building blocks of life. The algorithmic challenge of …

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of
proteins and other macromolecular complexes at near-atomic resolution. In single particle …

Single particle cryo-EM excels in determining static structures of biological macromolecules
such as proteins. However, many proteins are dynamic, with their motion inherently linked to …

This article presents an original approach for extracting atomic-resolution landscapes of
continuous conformational variability of biomolecular complexes from cryo electron …

Single-particle cryo-electron microscopy (cryo-EM) is a technique for biomolecular structure
reconstruction from vitrified samples containing many copies of a biomolecular complex …

Cryo-electron microscopy (cryo-EM) extracts single-particle density projections of individual
biomolecules. Although cryo-EM is widely used for 3D reconstruction, due to its single …