Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

While the long noncoding RNAs (ncRNAs) constitute a large portion of the mammalian
transcriptome, their biological functions has remained elusive. A few long ncRNAs that have …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in
morphology and expression of pluripotency factors than ES cells cultured in defined medium …

The three-dimensional organization of chromosomes within the nucleus and its dynamics
during differentiation are largely unknown. To visualize this process in molecular detail, we …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

The transcriptional networks that regulate embryonic stem (ES) cell pluripotency and lineage
specification are the subject of considerable attention. To date such studies have focused …