Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Unearthing the mechanisms of responsive neurostimulation for epilepsy

VR Rao, JD Rolston - Communications Medicine, 2023 - nature.com
Responsive neurostimulation (RNS) is an effective therapy for people with drug-resistant
focal epilepsy. In clinical trials, RNS therapy results in a meaningful reduction in median …

Deep brain stimulation of symptom-specific networks in Parkinson's disease

N Rajamani, H Friedrich, K Butenko, T Dembek… - Nature …, 2024 - nature.com
Abstract Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial
symptoms in patients with Parkinson's disease. Potentially, improving each symptom may …

[HTML][HTML] Lead-DBS v3. 0: Map** deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

Map** dysfunctional circuits in the frontal cortex using deep brain stimulation

B Hollunder, JL Ostrem, IA Sahin, N Rajamani… - Nature …, 2024 - nature.com
Frontal circuits play a critical role in motor, cognitive and affective processing, and their
dysfunction may result in a variety of brain disorders. However, exactly which frontal …

Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

A Horn, MM Reich, S Ewert, N Li, B Al-Fatly… - Proceedings of the …, 2022 - pnas.org
Dystonia is a debilitating disease with few treatment options. One effective option is deep
brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …

Hypothalamic deep brain stimulation augments walking after spinal cord injury

N Cho, JW Squair, V Aureli, ND James, L Bole-Feysot… - Nature medicine, 2024 - nature.com
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the
spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed …

Proceedings of the eighth annual deep brain stimulation think tank: advances in optogenetics, ethical issues affecting DBS research, neuromodulatory approaches for …

V Vedam-Mai, K Deisseroth, J Giordano… - Frontiers in Human …, 2021 - frontiersin.org
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to
address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters …

Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation

T Tsuboi, JK Wong, RS Eisinger, L Okromelidze… - Brain, 2021 - academic.oup.com
The pathophysiology of dystonic tremor and essential tremor remains partially understood.
In patients with medication-refractory dystonic tremor or essential tremor, deep brain …

White matter variability, cognition, and disorders: a systematic review

SJ Forkel, P Friedrich, M Thiebaut de Schotten… - Brain Structure and …, 2022 - Springer
Inter-individual differences can inform treatment procedures and—if accounted for—have
the potential to significantly improve patient outcomes. However, when studying brain …