The Mouse Metabolic Phenoty** Center (MMPC) Consortium was established to address
the need to characterize the growing number of mouse models of metabolic diseases …

The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive
research is urgently needed whereby experimental models represent an essential tool to …

The pathophysiology of diabetes as a disease is characterised by an inability to maintain
normal glucose homeostasis. In type 1 diabetes, this is due to autoimmune destruction of the …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

α2-HS glycoprotein (AHSG), also known as fetuin-A, inhibits insulin receptor
autophosphorylation and tyrosine kinase activity in vitro and in vivo. Earlier we have shown …

While considerable research has examined diminished insulin responses within peripheral
tissues, comparatively little has been done to examine the effects of this metabolic disruption …

Muscle atrophy in many conditions share a common mechanism in the upregulation of the
muscle-specific ubiquitin E3-ligases atrophy gene-1/muscle atrophy F-box (Atrogin …

Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …

There is a large body of evidence that biological aging is related to a series of long-term
catabolic processes resulting in decreased function and structural integrity of several …

We have previously shown that hexarelin, a novel GH-releasing peptide (GHRP), is able to
elicit GH release when administered iv, sc or by mouth and that it is a more potent GH …