Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Components of transcriptional machinery are selectively partitioned into specific
condensates, often mediated by protein disorder, yet we know little about how this specificity …

Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies
represent membraneless organelles, or condensates, that form via liquid–liquid phase …

Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit
coactivators and the transcriptional machinery to genes. Phase-separated condensates of …

Liquid–liquid phase separation (LLPS) is involved in the formation of membraneless
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …

Many biomolecular condensates form via spontaneous phase transitions that are driven by
multivalent proteins. These molecules are biological instantiations of associative polymers …

Proteins that undergo liquid–liquid phase separation (LLPS) have been shown to play a
critical role in many physiological functions through formation of condensed liquid-like …

Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the
formation of membraneless organelles, which compartmentalize molecules intracellularly in …

We present improvements to the hydropathy scale (HPS) coarse‐grained (CG) model for
simulating sequence‐specific behavior of intrinsically disordered proteins (IDPs), including …