Targeting human Glucokinase for the treatment of type 2 diabetes: an overview of allosteric Glucokinase activators
Diabetes mellitus is a worldwide impacting disorder and the ratio through which the number
of diabetic patients had increased worldwide, puts medical professionals to serious stress …
of diabetic patients had increased worldwide, puts medical professionals to serious stress …
A comprehensive review on glucokinase activators: promising agents for the treatment of type 2 diabetes
R Thilagavathi, MS Hosseini‐Zare… - Chemical Biology & …, 2022 - Wiley Online Library
Glucokinase is a key enzyme which converts glucose into glucose‐6‐phosphate in the liver
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …
Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus
A Khan, A Unnisa, M Sohel, M Date, N Panpaliya… - In Silico …, 2021 - Springer
Glucokinase (GK) is an enzyme involved in synthesising glucose into glucose-6 phosphate
and serves a crucial function in glucose sensing. Therefore, agents that induce GK activation …
and serves a crucial function in glucose sensing. Therefore, agents that induce GK activation …
The index of ideality of correlation: A statistical yardstick for better QSAR modeling of glucokinase activators
M Nimbhal, K Bagri, P Kumar, A Kumar - Structural Chemistry, 2020 - Springer
Glucokinase is an enzyme which is responsible for the conversion of glucose to glucose-6-
phosphate through ATP-dependent phosphorylation and has a significant role in glycogen …
phosphate through ATP-dependent phosphorylation and has a significant role in glycogen …
[HTML][HTML] Molecular docking, 2D-QSAR and ADMET studies of 4-sulfonyl-2-pyridone heterocycle as a potential glucokinase activator
Glucokinase is one of the key enzymes for the management of diabetes mellitus. Although
the literature has reported numerous molecules for lowering the blood glucose level, still no …
the literature has reported numerous molecules for lowering the blood glucose level, still no …
Recent developments in medicinal chemistry of allosteric activators of human glucokinase for type 2 diabetes mellitus therapeutics
Background: Glucokinase (GK), a cytoplasmic enzyme catalyzes the metabolism of glucose
to glucose-6-phosphate with the help of ATP and aids in the controlling of blood glucose …
to glucose-6-phosphate with the help of ATP and aids in the controlling of blood glucose …
Novel and emerging therapeutic drug targets for management of type 2 diabetes mellitus
DM (Diabetes Mellitus) can be divided to type 1 and type 2, but out of both, type 2 is more
predominant form of diabetes. At present approximate more than 451 million people (1 in 11 …
predominant form of diabetes. At present approximate more than 451 million people (1 in 11 …
Design, synthesis and antiproliferative activity of new amine, amino acid and dipeptide-coupled benzamides as potential sigma-1 receptor
E Youssef, MA El-Moneim, W Fathalla… - Journal of the Iranian …, 2020 - Springer
Abstract N-Alkyl-2-(substitutedbenzamido) benzamides and methyl 2-(2-
(substitutedbenzamido) benzamido) alkanoates were prepared by either the reaction of …
(substitutedbenzamido) benzamido) alkanoates were prepared by either the reaction of …
Hetero-substituted sulfonamido-benzamide hybrids as glucokinase activators: Design, synthesis, molecular docking and in-silico ADME evaluation
SC Khadse, ND Amnerkar, KS Dighole… - Journal of Molecular …, 2020 - Elsevier
A series of hetero-substituted sulphonamido-benzamide derivatives which can activate
glucokinase (GK) were synthesized and screened in-vitro using Human GK activation assay …
glucokinase (GK) were synthesized and screened in-vitro using Human GK activation assay …
N‐pyridin‐2‐yl benzamide analogues as allosteric activators of glucokinase: Design, synthesis, in vitro, in silico and in vivo evaluation
Glucokinase (GK) is the key enzyme controlling levels of blood glucose under normal
physiological range, and GK activators are emerging class of drug candidates with …
physiological range, and GK activators are emerging class of drug candidates with …