RNA-binding proteins in cancer: old players and new actors

B Pereira, M Billaud, R Almeida - Trends in cancer, 2017 - cell.com
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

RNA-binding proteins and cancer metastasis

S Wang, Z Sun, Z Lei, HT Zhang - Seminars in cancer biology, 2022 - Elsevier
RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

RNA-binding proteins hold key roles in function, dysfunction, and disease

S Kelaini, C Chan, VA Cornelius, A Margariti - Biology, 2021 - mdpi.com
Simple Summary Chronic hyperglycemia manifests in a variety of different micro-and
macrovascular disorders such as diabetes mellitus and cardiovascular disease and has …

[HTML][HTML] RNA binding protein as an emerging therapeutic target for cancer prevention and treatment

S Hong - Journal of cancer prevention, 2017 - ncbi.nlm.nih.gov
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to
perform biological activities. RBPs can interact with target RNAs in sequence-and structure …

Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA)

R Cao, L Yuan, B Ma, G Wang, Y Tian - Cancer cell international, 2020 - Springer
Background As bladder cancer was recognized to be immunogenic, dozens of studies have
focused on immune biology of BLCA, but little is known about its relationship with the long …

Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer

J Yan, DD Kang, G Turnbull, Y Dong - Advanced drug delivery reviews, 2022 - Elsevier
RNA-binding proteins (RBPs) play an important role in RNA metabolism, regulating the
stability, localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network …

Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma

BR Correa, PR de Araujo, M Qiao, SC Burns, C Chen… - Genome Biology, 2016 - Springer
Background Glioblastoma (GBM) is the most common and aggressive type of brain tumor.
Currently, GBM has an extremely poor outcome and there is no effective treatment. In this …

Proteomics-based identification of dysregulated proteins in breast cancer

AN Neagu, M Jayathirtha, D Whitham, P Mutsengi… - Proteomes, 2022 - mdpi.com
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

C Yi, G Li, DN Ivanov, Z Wang, MX Velasco… - RNA biology, 2018 - Taylor & Francis
ABSTRACT RNA binding proteins have emerged as critical oncogenic factors and potential
targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy …

RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC

M Majumder, R House, N Palanisamy, S Qie… - PLoS …, 2016 - journals.plos.org
RNA-binding proteins (RBP) regulate numerous aspects of co-and post-transcriptional gene
expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 …