The role of Epstein–Barr virus in nasopharyngeal carcinoma

ZY Su, PY Siak, CO Leong, SC Cheah - Frontiers in microbiology, 2023 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy closely associated
with the Epstein–Barr virus (EBV). Despite ubiquitous infection of EBV worldwide, NPC …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Targeting Epstein-Barr virus in nasopharyngeal carcinoma

PM Hau, HL Lung, M Wu, CM Tsang, KL Wong… - Frontiers in …, 2020 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV)
infection in regions in which it is endemic, including Southern China and Southeast Asia …

Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway

D Xu, T Kong, S Zhang, B Cheng, J Chen, C Wang - Cellular Signalling, 2021 - Elsevier
Orexin A (OXA) is a neuroprotective peptide that exerts protective effects on multiple
physiological and pathological processes. Activation of autophagy is linked to the …

[HTML][HTML] Lytic induction therapy against Epstein–Barr virus-associated malignancies: past, present, and future

SPT Yiu, M Dorothea, KF Hui, AKS Chiang - Cancers, 2020 - mdpi.com
Epstein–Barr virus (EBV) lytic induction therapy is an emerging virus-targeted therapeutic
approach that exploits the presence of EBV in tumor cells to confer specific killing effects …

Therapeutic approaches to Epstein–Barr virus cancers

SS Soldan, TE Messick, PM Lieberman - Current opinion in virology, 2022 - Elsevier
Epstein–Barr virus (EBV) establishes a lifelong latent infection that can be a causal agent for
a diverse spectrum of cancers and autoimmune disease. A complex and dynamic viral …

Viral-targeted strategies against EBV-associated lymphoproliferative diseases

KF Hui, SPT Yiu, KP Tam, AKS Chiang - Frontiers in Oncology, 2019 - frontiersin.org
Epstein-Barr virus (EBV) is strongly associated with a spectrum of EBV-associated
lymphoproliferative diseases (EBV-LPDs) ranging from post-transplant lymphoproliferative …

Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase

J Dheekollu, A Wiedmer, SS Soldan… - PLoS …, 2023 - journals.plos.org
Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is causally associated
with various malignancies and autoimmune disease. Epstein-Barr Nuclear Antigen 1 …

Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK/mTOR signaling pathway

D Zhang, Y Cui, M Zhao, X Zheng, C Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Orexin-A (OXA) is a polypeptide produced in the hypothalamus, which binds to
specific receptors and exerts multiple physiological effects. Autophagy plays a vital role in …

Reactivation of epstein-barr virus by HIF-1α requires p53

RJ Kraus, BA Cordes, S Sathiamoorthi, P Patel… - Journal of …, 2020 - journals.asm.org
We previously reported that the cellular transcription factor hypoxia-inducible factor 1α (HIF-
1α) binds a hypoxia response element (HRE) located within the promoter of Epstein-Barr …