Gap junctions and cancer: communicating for 50 years
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …
that loss of direct intercellular communication is commonly associated with cancer onset and …
Connexins in cancer: bridging the gap to the clinic
T Aasen, E Leithe, SV Graham, P Kameritsch… - Oncogene, 2019 - nature.com
Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …
provide for the direct communication between adjacent cells. This type of intercellular …
Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
MZ Totland, NL Rasmussen, LM Knudsen… - Cellular and Molecular …, 2020 - Springer
Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …
communicate both electrically and metabolically. Gap junctions have a wide diversity of …
Connexins: synthesis, post-translational modifications, and trafficking in health and disease
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …
direct intercellular communication, a critical feature for the development, function, and …
Connexins: key players in the control of vascular plasticity and function
U Pohl - Physiological reviews, 2020 - journals.physiology.org
Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …
The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets
Considering the fact that cancer cells can switch among various molecular pathways and
mechanisms to ensure their progression, chemotherapy is no longer effective enough in …
mechanisms to ensure their progression, chemotherapy is no longer effective enough in …
Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread
Cell-to-cell communication is essen for the development of multicellular systems and is
coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently …
coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently …
Insights into the role of connexins and specialized intercellular communication pathways in breast cancer: mechanisms and applications
MRC Mateos, P Carpintero-Fernández… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Gap junctions, membrane-based channels comprised of connexin proteins (Cxs), facilitate
direct communication among neighbouring cells and between cells and the extracellular …
direct communication among neighbouring cells and between cells and the extracellular …
Connexins in cancer: Jekyll or Hyde?
The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …
[HTML][HTML] Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight …
AM Johnson, JP Roach, A Hu, SM Stamatovic… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Familial cerebral cavernous malformations type III (fCCM3) is a disease of the
cerebrovascular system caused by loss-of-function mutations in ccm3 that result in dilated …
cerebrovascular system caused by loss-of-function mutations in ccm3 that result in dilated …