Losing DNA methylation at repetitive elements and breaking bad

XG Pappalardo, V Barra - Epigenetics & chromatin, 2021 - Springer
Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …

Repetitive elements in aging and neurodegeneration

KE Copley, J Shorter - Trends in Genetics, 2023 - cell.com
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

Epigenetic changes and its intervention in age-related neurodegenerative diseases

N Mohd Murshid, F Aminullah Lubis… - Cellular and molecular …, 2022 - Springer
Epigenetic mechanisms involving the modulation of gene activity without modifying the DNA
bases are reported to have lifelong effects on mature neurons in addition to their impact on …

Health repercussions of environmental exposure to lead: Methylation perspective

SS Shiek, MS Mani, SP Kabekkodu, HS Dsouza - Toxicology, 2021 - Elsevier
Lead (Pb) exposure has been a major public health concern for a long time now due to its
permanent adverse effects on the human body. The process of lead toxicity has still not been …

Aberrant methylation of LINE-1 transposable elements: a search for cancer biomarkers

AA Ponomaryova, EY Rykova, PA Gervas… - Cells, 2020 - mdpi.com
Cancer remains one of the main causes of human mortality despite significant progress in its
diagnostics and therapy achieved in the past decade. Massive hypomethylation of …

[HTML][HTML] Wildfire-related PM2. 5 and DNA methylation: An Australian twin and family study

R Xu, S Li, Y Wu, X Yue, EM Wong, MC Southey… - Environment …, 2023 - Elsevier
Background Wildfire-related fine particulate matter (PM 2.5) has many adverse health
impacts, but its impacts on human epigenome are unknown. We aimed to evaluate the …

Airway aging and methylation disruptions in HIV-associated chronic obstructive pulmonary disease

AI Hernández Cordero, CX Yang, J Yang… - American Journal of …, 2022 - atsjournals.org
Rationale: Age-related diseases like chronic obstructive pulmonary disease (COPD) occur
at higher rates in people living with human immunodeficiency virus (PLWH) than in …

Circulating cell-free nucleic acids of plasma in human aging, healthy aging and longevity: current state of knowledge

NP Tessier, LM Hardy, JF Deleuze, A How-Kit - Frontiers in Genetics, 2023 - frontiersin.org
Circulating cell-free nucleic acids (ccfNAs) of plasma are a remarkable source of genetic,
epigenetic and transcriptomic materials originating from different cells, tissues and organs of …

Promising epigenetic biomarkers for the early detection of colorectal cancer: a systematic review

SA Anghel, CB Ioniță-Mîndrican, I Luca, AL Pop - Cancers, 2021 - mdpi.com
Simple Summary High-performance, non-invasive screening is a requirement in colorectal
cancer (CRC) as early detection is a key in reducing disease-related mortality in CRC …

Methyl group metabolism in differentiation, aging, and cancer

L Erichsen, C Thimm, S Santourlidis - International journal of molecular …, 2022 - mdpi.com
Methyl group metabolism belongs to a relatively understudied field of research. Its
importance lies in the fact that methyl group metabolic pathways are crucial for the …