In spite of its impressive record in medicinal chemistry, the role of barbituric acid H 3 BA
(pyrimidine-2, 4, 6 (1H, 3H, 5H)-trione) in coordination, organometallic and supramolecular …

This chapter discusses the phenomenon of polymorphism in organic and organometallic
compounds. Polymorphism is first introduced and then, to give the work some context …

Following the interest generated by two previous blind tests of crystal structure prediction
(CSP1999 and CSP2001), a third such collaborative project (CSP2004) was hosted by the …

Engineering crystal properties by a choice of adequate molecular building blocks has to
cope with the fact that a given molecule can be isolated in many, at times very many, solid …

Two polymorphs of the well-known diuretic drug Lasix, generic name furosemide, are
characterized by single crystal X-ray diffraction to give a trimorphic cluster of polymorphs …

Five new polymorphs and one hydrated form of 2‐thiobarbituric acid have been isolated and
characterised by solid‐state methods. In both the crystalline form II and in the hydrate form …

Pharmaceutical co-crystals are multicomponent molecular systems typically formed through
hydrogen bonding of a co-former molecule with the active pharmaceutical ingredient (API) …

Barbituric acid, which has been known since 1863,[1] is drawn in textbooks always as the
keto tautomeric form 1 (Scheme 1). Indeed, this is the most stable form in the gas phase [2] …

Performing reactions in the solid state offers the largely unexplored possibility of influencing
reactivity by manipulating the solid form of the starting reactants. In this work, we explore the …

The novel carboxamide–pyridine N-oxide synthon, sustained via N–H⋯ O− hydrogen
bonding and C–H⋯ O interaction, is shown to assemble isonicotinamide N-oxide in a triple …