Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic
endo/lysosomal compartments where they play a vital role in intracellular protein …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Proteases are ubiquitous enzymes, having significant physiological roles in both synthesis
and degradation. The use of microbial proteases in food fermentation is an age-old process …

Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

Diabetic retinopathy (DR) is a serious complication of diabetes mellitus and currently one of
the major causes of blindness. Several previous studies have demonstrated that autophagy …

Abstract Purpose of Review Allergen is an umbrella term for irritants of diverse origin. Along
with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …