The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

Objective: Machine learning classification has been the most important computational
development in the last years to satisfy the primary need of clinicians for automatic early …

There is an increasing role for biological markers (biomarkers) in the understanding and
diagnosis of neurodegenerative disorders. The application of imaging biomarkers …

It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …

White matter alterations are present in the majority of patients with Alzheimer's disease type
dementia. However, the spatiotemporal pattern of white matter changes preceding dementia …

Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder with a clinical
presentation characterized by memory impairment and executive dysfunction. Our group …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current
avenues of AD research focus on pre-symptomatic biomarkers that will assist with early …

The development of early non-invasive diagnosis methods and identification of novel
biomarkers are necessary for managing Alzheimer's disease (AD) and facilitating effective …

Brain imaging with diffusion-weighted MRI (dMRI) is sensitive to microstructural white matter
(WM) changes associated with brain aging and neurodegeneration. In its third phase, the …

The search for diagnostic and prognostic biomarkers for neurodegenerative conditions is of
high importance, since these disorders may present difficulties in differential diagnosis …