The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our
understanding of cancer's common traits and in rational drug design. Not free of critique and …

Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and
therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …

Reactive oxygen species (ROS) have emerged as important signaling molecules that play
crucial roles in carcinogenesis and cytotoxic responses. Nrf2 is the master regulator of ROS …

P53 is known as the most critical tumor suppressor and is often referred to as the guardian of
our genome. More than 40 years after its discovery, we are still struggling to understand all …

Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually
arising on a background of chronic liver injury involving inflammatory and hepatic …

The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of
human cancers are associated with the loss of p53 functions, where p53 often accumulates …

Although the associations of p53 dysfunction, p53 interaction networks and oncogenesis
have been widely explored, a systematic analysis of TP53 mutations and its related …

Simple Summary Cyclin-dependent kinase inhibitors (palbociclib (Ibrance), ribociclib
(Kisqali), and abemaciclib (Verzenio)), targeting aberrant cell-cycle activity have been …

Background: Tumor mutation burden (TMB) have been served as the most prevalent
biomarkers to predict immunotherapy response. LRP1B (low-density lipoprotein receptor …