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Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Role of pyroptosis in inflammation and cancer
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …
Histone post-translational modifications—cause and consequence of genome function
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
[HTML][HTML] Functional partitioning of transcriptional regulators by patterned charge blocks
Components of transcriptional machinery are selectively partitioned into specific
condensates, often mediated by protein disorder, yet we know little about how this specificity …
condensates, often mediated by protein disorder, yet we know little about how this specificity …
Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Modulation of cellular processes by histone and non-histone protein acetylation
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Capillary forces generated by biomolecular condensates
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
[HTML][HTML] A disordered region controls cBAF activity via condensation and partner recruitment
Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …
Liquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …