Among various matrix metalloproteinases (MMPs), MMPs having medium-size S1′ pockets
are established as promising biomolecular targets for executing crucial roles in cancer …

Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due
to the existence of other spindle-cell shaped sarcomas, its diagnosis is always one of …

A central question in stem cell biology is the relationship between stem cells and their niche.
Although previous reports have uncovered how signaling molecules released by niche cells …

Rheumatoid arthritis (RA) is a chronic, autoimmune pathology characterized by persistent
synovial inflammation and gradually advancing bone destruction. Matrix metalloproteinases …

Omentum metastasis is a common occurrence in epithelial ovarian cancer (EOC), which is
often accompanied by ascites that facilitates the spread of EOC cells. A subpopulation of …

During myocardial ischemia and reperfusion (IR) injury matrix metalloproteinase-2 (MMP-2)
is rapidly activated in response to oxidative stress. MMP-2 is a multifunctional protease that …

Ischemic heart disease remains a leading cause of human mortality worldwide. One form of
ischemic heart disease is ischemia–reperfusion injury caused by the reintroduction of blood …

Melanoma cells express high levels of CD73 that produce extracellular immunosuppressive
adenosine. Changes in the CD73 expression occur in response to tumor environmental …

Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and
elderly patients, and is characterized by progressive loss of articular cartilage that eventually …

Background Seeking addictive drugs is regulated by synaptic plasticity in the nucleus
accumbens core and involves distinct plasticity in D 1 and D 2 receptor–expressing medium …