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[HTML][HTML] Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update
GE Jimenez-Gutierrez, LE Martínez-Gómez… - Cells, 2022 - mdpi.com
Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …
What is nuclear factor kappa B (NF-κB) doing in and to the mitochondrion?
A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling
contributes to not only immunity, but also inflammation, cancer, and nervous system function …
contributes to not only immunity, but also inflammation, cancer, and nervous system function …
[HTML][HTML] Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression
Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …
equilibrium between its fission and fusion rates. Understanding the factors influencing this …
[HTML][HTML] Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
The selective removal of undesired or damaged mitochondria by autophagy, known as
mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion …
mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion …
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Mitochondrial quality control is central for maintaining a healthy population of mitochondria.
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin …
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin …
[HTML][HTML] Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response
Memory T cells are thought to rely on oxidative phosphorylation and short-lived effector T
cells on glycolysis. Here, we investigated how T cells arrive at these states during an …
cells on glycolysis. Here, we investigated how T cells arrive at these states during an …
The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging
The receptor for advanced glycation end-products (RAGE) was initially characterized and
named for its ability to bind to advanced glycation end-products (AGEs) that form upon the …
named for its ability to bind to advanced glycation end-products (AGEs) that form upon the …
Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading
Sustained nutrient (fuel) excess, as occurs during obesity and diabetes, has been linked to
increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin …
increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin …
Mitochondrial fission mediates endothelial inflammation
Endothelial inflammation and mitochondrial dysfunction have been implicated in
cardiovascular diseases, yet, a unifying mechanism tying them together remains limited …
cardiovascular diseases, yet, a unifying mechanism tying them together remains limited …