The chemistry of heterocycles in the 21st century

VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Nitrogen-containing heterocyclic compounds obtained from monoterpenes or their derivatives: synthesis and properties

VV Chernyshov, II Popadyuk, OI Yarovaya… - Topics in Current …, 2022 - Springer
Directed transformation of available natural compounds with native biological activity is a
promising area of research in organic and medicinal chemistry aimed at finding effective …

Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol

X Hu, Y Yan, W Liu, J Liu, T Fan, H Deng, Y Cai - Phytomedicine, 2024 - Elsevier
Background Borneol, a highly lipid-soluble bicyclic terpene mainly extracted from plants, is
representative of monoterpenoids. Modern medicine has established that borneol exhibits a …

Molecular Modeling of Viral Type I Fusion Proteins: Inhibitors of Influenza Virus Hemagglutinin and the Spike Protein of Coronavirus

SS Borisevich, VV Zarubaev, DN Shcherbakov… - Viruses, 2023 - mdpi.com
The fusion of viral and cell membranes is one of the basic processes in the life cycles of
viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell …

Essential oils from Colombian plants: Antiviral potential against dengue virus based on chemical composition, in vitro and in silico analyses

L Silva-Trujillo, E Quintero-Rueda, EE Stashenko… - Molecules, 2022 - mdpi.com
Currently, there are no therapies to prevent severe dengue disease. Essential oils (EOs) can
serve as primary sources for research and the discovery of phytomedicines for alternative …

(+)-Usnic acid and its derivatives as inhibitors of a wide spectrum of SARS-CoV-2 viruses

AS Filimonov, OI Yarovaya, AV Zaykovskaya… - Viruses, 2022 - mdpi.com
In order to test the antiviral activity, a series of usnic acid derivatives were synthesized,
including new, previously undescribed compounds. The activity of the derivatives against …

[PDF][PDF] Antiviral properties of diterpenes and their derivatives

OI Yarovaya, SS Laev, NF Salakhutdinov - Russ. Chem. Rev, 2023 - researchgate.net
Virus is a noncellular infectious agent that reproduces only inside living cells. Viruses infect
various types of organisms such as bacteria, plants, animals and humans. The officially …

Discovery of new ginsenol-like compounds with high antiviral activity

AS Volobueva, OI Yarovaya, MV Kireeva… - Molecules, 2021 - mdpi.com
A number of framework amides with a ginsenol backbone have been synthesized using the
Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the …

Synthesis and in vitro study of antiviral activity of glycyrrhizin nicotinate derivatives against HIV-1 pseudoviruses and SARS-CoV-2 viruses

VV Fomenko, NB Rudometova, OI Yarovaya… - Molecules, 2022 - mdpi.com
When develo** drugs against SARS-CoV-2, it is important to consider the characteristics
of patients with different co-morbidities. People infected with HIV-1 are a particularly …

Design, Synthesis, and Biological Evaluation of (+)‐Camphor‐and (−)‐Fenchone‐Based Derivatives as Potent Orthopoxvirus Inhibitors

AS Sokolova, KS Kovaleva, SO Kuranov… - …, 2022 - Wiley Online Library
In this work, a library of (+)‐camphor and (−)‐fenchone based N‐acylhydrazones, amides,
and esters, including para‐substituted aromatic/hetaromatic/cyclohexane ring was …