Guided bone regeneration (GBR) has become a clinically standard modality for the
treatment of localized jawbone defects. Barrier membranes play an important role in this …

A variety of engineered materials have gained acceptance in orthopedic practice as
substitutes for autologous bone grafts, although the regenerative efficacy of these …

Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of a fibrin
scaffold and its internal loading of growth factors, platelets, and leukocytes, with the gradual …

Rapid and efficient vascularization is still considerably challenging for a porous β-tricalcium
phosphate (β-TCP) scaffold to achieve. To overcome this challenge, branched channels …

Transfer of regenerative approaches into clinical practice is limited by strict legal regulation
of in vitro expanded cells and risks associated with substantial manipulations. Isolation of …

Bioactive glasses (BGs) have attracted significant attention in the biomaterials field due to
their ability to promote soft and hard tissue regeneration and their potential for various …

Purpose Autologous bone grafts are the gold standard for treating bone defects. However,
limited bone supply and morbidity at the donor site restrict its extensive use. Therefore …

The incorporation of bioactive ions into biomaterials has gained significant attention as a
strategy to enhance bone tissue regeneration on the molecular level. However, little …

The use of ions as therapeutic agents has the potential to minimize the use of small-
molecule drugs and biologics for the same purpose, thus providing a potentially more …

The physicochemical properties of synthetically produced bone substitute materials (BSM)
have a major impact on biocompatibility. This affects bony tissue integration …