[HTML][HTML] The potential cardiometabolic effects of long-chain ω-3 polyunsaturated fatty acids: recent updates and controversies
JH Bae, H Lim, S Lim - Advances in Nutrition, 2023 - Elsevier
Various health-related effects of long-chain (LC) ω-3 PUFAs, EPA, and DHA have been
suggested. LC ω-3 PUFAs reduce TG concentrations and have anti-inflammatory …
suggested. LC ω-3 PUFAs reduce TG concentrations and have anti-inflammatory …
Cardiac fibroblasts and mechanosensation in heart development, health and disease
The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …
into the coordinated regulation of intracellular signals, cellular function, gene expression …
Piezo1 channels contribute to the regulation of human atrial fibroblast mechanical properties and matrix stiffness sensing
R Emig, W Knodt, MJ Krussig, CM Zgierski-Johnston… - Cells, 2021 - mdpi.com
The mechanical environment of cardiac cells changes continuously and undergoes major
alterations during diseases. Most cardiac diseases, including atrial fibrillation, are …
alterations during diseases. Most cardiac diseases, including atrial fibrillation, are …
MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels
Piezo channels are critical cellular sensors of mechanical forces. Despite their large size,
ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological …
ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological …
Channelling the force to reprogram the matrix: Mechanosensitive ion channels in cardiac fibroblasts
L Stewart, NA Turner - Cells, 2021 - mdpi.com
Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics
Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …
Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction
Although cardiac action potential (AP) generation and propagation have traditionally been
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …
Regulation of PIEZO1 channels by lipids and the structural components of extracellular matrix/cell cytoskeleton
V Vasileva… - Journal of Cellular …, 2023 - Wiley Online Library
PIEZO1 is a mechanosensitive channel widely presented in eukaryotic organisms. Although
the PIEZO family was discovered in 2010, main questions related to the molecular structure …
the PIEZO family was discovered in 2010, main questions related to the molecular structure …
[HTML][HTML] Mechanical stress regulates the mechanotransduction and metabolism of cardiac fibroblasts in fibrotic cardiac diseases
G Tian, T Ren - European Journal of Cell Biology, 2023 - Elsevier
Fibrotic cardiac diseases are characterized by myocardial fibrosis that results in maladaptive
cardiac remodeling. Cardiac fibroblasts (CFs) are the main cell type responsible for fibrosis …
cardiac remodeling. Cardiac fibroblasts (CFs) are the main cell type responsible for fibrosis …
Piezo1 channel as a potential target for hindering cardiac fibrotic remodeling
Fibrotic tissues share many common features with neoplasms where there is an increased
stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries …
stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries …