Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson's disease and other
synucleinopathies. These inclusions predominantly localize to axons even in the early …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

The specialized architecture of neurons necessitates unique modes of intracellular
communication to allow for cell survival, the ability to detect and respond to injury and …

Adiponectin, an adipokine secreted by the white adipose tissue, plays an important role in
regulating glucose and lipid metabolism and controlling energy homeostasis in insulin …

Increasing evidence links intraneuronal β-amyloid (Aβ42) accumulation with the
pathogenesis of Alzheimer's disease (AD). In Aβ precursor protein (APP) mutant transgenic …

Throughout the brain, postsynaptic neurons release substances from their cell bodies and
dendrites that regulate the strength of the synapses they receive. Diverse chemical …

Neuronal connections are established and refined through a series of developmental
programs that involve axon and dendrite specification, process growth, target innervation …