Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

Nicotinamide adenine dinucleotide (NAD+) is a classical coenzyme mediating many redox
reactions. NAD+ also plays an important role in the regulation of NAD+-consuming …

Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

Despite tremendous growth in recent years in our knowledge of the molecular basis of
Parkinson disease (PD) and the molecular pathways of cell injury and death, we remain …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Parkinson's disease (PD) is the most common neurodegenerative disease of the basal
ganglia. Like other adult-onset neurodegenerative disorders, it is without a treatment that …

Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia
neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD+) …

Axon degeneration is a characteristic event in many neurodegenerative conditions including
stroke, glaucoma, and motor neuropathies. However, the molecular pathways that regulate …