Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a
wide range of physiological processes, but their in vivo dynamics remain largely …

A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to
the death of one volunteer and produced mild-to-severe neurological symptoms in four …

Identification of risk variants for neuropsychiatric diseases within enhancers underscores the
importance of understanding population-level variation in enhancer function in the human …

Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

The brain's endocannabinoid system is a powerful controller of neurotransmitter release,
sha** synaptic communication under physiological and pathological conditions. However …

Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …

Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …