Lipid metabolism in regulation of macrophage functions

J Yan, T Horng - Trends in cell biology, 2020 - cell.com
Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

Lipid droplets: platforms with multiple functions in cancer hallmarks

ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

J Marschallinger, T Iram, M Zardeneta, SE Lee… - Nature …, 2020 - nature.com
Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …

Nitric oxide in macrophage immunometabolism: hiding in plain sight

EM Palmieri, C McGinity, DA Wink, DW McVicar - Metabolites, 2020 - mdpi.com
Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …

Dengue virus capsid protein usurps lipid droplets for viral particle formation

MM Samsa, JA Mondotte, NG Iglesias… - PLoS …, 2009 - journals.plos.org
Dengue virus is responsible for the highest rates of disease and mortality among the
members of the Flavivirus genus. Dengue epidemics are still occurring around the world …

Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

APJ De Vries, P Ruggenenti, XZ Ruan… - The lancet Diabetes & …, 2014 - thelancet.com
The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity
conveys a gradual but independent risk of progression of CKD that seems irrespective of the …

Not just fat: the structure and function of the lipid droplet

T Fujimoto, RG Parton - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and
a surface phospholipid monolayer. Recent studies have revealed many new proteins …

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

MJ Kim, HC Wainwright, M Locketz… - EMBO molecular …, 2010 - embopress.org
The progression of human tuberculosis (TB) to active disease and transmission involves the
development of a caseous granuloma that cavitates and releases infectious Mycobacterium …

Lipid droplets and lipid mediators in viral infection and immunity

EA Monson, AM Trenerry, JL Laws… - FEMS microbiology …, 2021 - academic.oup.com
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Lipid droplets in inflammation and cancer

PT Bozza, JPB Viola - … , Leukotrienes and Essential Fatty Acids (PLEFA), 2010 - Elsevier
Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes,
epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed …