Lipid metabolism in regulation of macrophage functions
J Yan, T Horng - Trends in cell biology, 2020 - cell.com
Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …
Lipid droplets: platforms with multiple functions in cancer hallmarks
ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …
genetic studies have linked these cells to the pathogenesis of a growing number of …
Nitric oxide in macrophage immunometabolism: hiding in plain sight
Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …
signaling, and working as an effector molecule or metabolic regulator. In response to …
Dengue virus capsid protein usurps lipid droplets for viral particle formation
MM Samsa, JA Mondotte, NG Iglesias… - PLoS …, 2009 - journals.plos.org
Dengue virus is responsible for the highest rates of disease and mortality among the
members of the Flavivirus genus. Dengue epidemics are still occurring around the world …
members of the Flavivirus genus. Dengue epidemics are still occurring around the world …
Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease
The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity
conveys a gradual but independent risk of progression of CKD that seems irrespective of the …
conveys a gradual but independent risk of progression of CKD that seems irrespective of the …
Not just fat: the structure and function of the lipid droplet
Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and
a surface phospholipid monolayer. Recent studies have revealed many new proteins …
a surface phospholipid monolayer. Recent studies have revealed many new proteins …
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
MJ Kim, HC Wainwright, M Locketz… - EMBO molecular …, 2010 - embopress.org
The progression of human tuberculosis (TB) to active disease and transmission involves the
development of a caseous granuloma that cavitates and releases infectious Mycobacterium …
development of a caseous granuloma that cavitates and releases infectious Mycobacterium …
Lipid droplets and lipid mediators in viral infection and immunity
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …
Lipid droplets in inflammation and cancer
Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes,
epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed …
epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed …