Accumulating laboratory studies have implicated the mobilization of bone marrow (BM)-
derived stem cells in brain plasticity and stroke therapy. This mobilization of bone cells to the …

BACKGROUND Both pluripotent very small embryonic-like stem cells (VSELs) and induced
pluripotent stem (iPS) cells were reported in 2006. In 2012, a Nobel Prize was awarded for …

Mobilizing bone cells to the head, astutely referred to as 'bonehead'therapeutic approach,
represents a major discipline of regenerative medicine. The last decade has witnessed …

The transcription factor octamer-binding transforming factor 4 (Oct-4) is central to the gene
regulatory network responsible for self-renewal, pluripotency, and lineage commitment in …

Background Developmentally early cells, including hematopoietic stem progenitor cells
(HSPCs), as well as very small embryonic-like stem cells (VSELs), are mobilized into …

Background We have earlier reported that follicle stimulating hormone (FSH) modulates
ovarian stem cells which include pluripotent, very small embryonic-like stem cells (VSELs) …

Despite extensive research, genetic basis of premature ovarian failure (POF) and ovarian
cancer still remains elusive. It is indeed paradoxical that scientists searched for mutations in …

Nasopharyngeal carcinoma (NPC) is a cancer common in southern China and South East
Asia that is causally linked to Epstein–Barr virus (EBV) infection. Here, we demonstrate that …

Adult tissues are thought to harbor two populations of “dormant” and “actively dividing” stem
cells. Quiescent stem cells undergo rare asymmetric cell divisions (ACDs) through which …

The concept that adult tissue, including bone marrow (BM), contains early-development cells
with broader differentiation potential has again been recently challenged. In response, we …