[HTML][HTML] Regulatory principles of pluripotency: from the ground state up
JA Hackett, MA Surani - Cell stem cell, 2014 - cell.com
Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell
types of an adult organism. This property can be captured indefinitely through derivation of …
types of an adult organism. This property can be captured indefinitely through derivation of …
[HTML][HTML] Lin28: primal regulator of growth and metabolism in stem cells
In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation
Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …
Resetting transcription factor control circuitry toward ground-state pluripotency in human
Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …
Establishment of porcine and human expanded potential stem cells
We recently derived mouse expanded potential stem cells (EPSCs) from individual
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …
[HTML][HTML] The transcriptional and epigenomic foundations of ground state pluripotency
H Marks, T Kalkan, R Menafra, S Denissov, K Jones… - Cell, 2012 - cell.com
Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in
morphology and expression of pluripotency factors than ES cells cultured in defined medium …
morphology and expression of pluripotency factors than ES cells cultured in defined medium …
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
The induction of pluripotent stem cells (iPSCs) by defined factors is poorly understood
stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary …
stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary …
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast
Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …
Despite sharing the common property of pluripotency, hESCs are notably distinct from …
Models of human core transcriptional regulatory circuitries
A small set of core transcription factors (TFs) dominates control of the gene expression
program in embryonic stem cells and other well-studied cellular models. These core TFs …
program in embryonic stem cells and other well-studied cellular models. These core TFs …