Chromosomal instability as a driver of cancer progression
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
Adherens junctions as molecular regulators of emergent tissue mechanics
Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …
coordinated action of many cells. Recent studies have revealed that tissue material …
[HTML][HTML] Non-cell-autonomous cancer progression from chromosomal instability
Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …
effect depends on the immune system remains unknown. Using ContactTracing—a newly …
Changes in tissue fluidity predict tumor aggressiveness in vivo
F Sauer, S Grosser, M Shahryari, A Hayn… - Advanced …, 2023 - Wiley Online Library
Cancer progression is caused by genetic changes and associated with various alterations in
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …
The force is strong with this epigenome: chromatin structure and mechanobiology
All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …
Multiple aspects of matrix stiffness in cancer progression
A Mancini, MT Gentile, F Pentimalli… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …
Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale
Here, we review recent developments in the literature that provide insight into self-
organization at supracellular scales in vertebrate organ morphogenesis. We briefly present …
organization at supracellular scales in vertebrate organ morphogenesis. We briefly present …
[HTML][HTML] Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
V Kumar, C Bauer, JH Stewart IV - European Journal of Cell Biology, 2023 - Elsevier
Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …
threats to mount a protective proinflammatory innate immune response. PRRs may be …
Mechanisms controlling the mechanical properties of the nuclei
G Bastianello, M Foiani - Current Opinion in Cell Biology, 2023 - Elsevier
The mechanical properties of the nucleus influence different cellular and nuclear functions
and have relevant implications for several human diseases. The nucleus protects genetic …
and have relevant implications for several human diseases. The nucleus protects genetic …
Brillouin microscopy
The field of Brillouin microscopy and imaging was established approximately 20 years ago,
thanks to the development of non-scanning high-resolution optical spectrometers. Since …
thanks to the development of non-scanning high-resolution optical spectrometers. Since …