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Adherens junctions as molecular regulators of emergent tissue mechanics
Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …
coordinated action of many cells. Recent studies have revealed that tissue material …
Chromosomal instability as a driver of cancer progression
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
[HTML][HTML] Non-cell-autonomous cancer progression from chromosomal instability
Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …
effect depends on the immune system remains unknown. Using ContactTracing—a newly …
Brillouin microscopy
The field of Brillouin microscopy and imaging was established approximately 20 years ago,
thanks to the development of non-scanning high-resolution optical spectrometers. Since …
thanks to the development of non-scanning high-resolution optical spectrometers. Since …
Changes in tissue fluidity predict tumor aggressiveness in vivo
Cancer progression is caused by genetic changes and associated with various alterations in
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …
cell properties, which also affect a tumor's mechanical state. While an increased stiffness …
Mechanism and role of nuclear laminin B1 in cell senescence and malignant tumors
Abstract Nuclear lamin B1 (LMNB1) is a member of the nuclear lamin protein family. LMNB1
can maintain and ensure the stability of nuclear structure and influence the process of cell …
can maintain and ensure the stability of nuclear structure and influence the process of cell …
Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale
Here, we review recent developments in the literature that provide insight into self-
organization at supracellular scales in vertebrate organ morphogenesis. We briefly present …
organization at supracellular scales in vertebrate organ morphogenesis. We briefly present …
Multiple aspects of matrix stiffness in cancer progression
The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …
[HTML][HTML] Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …
threats to mount a protective proinflammatory innate immune response. PRRs may be …
Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification
Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-
transduction pathways. We investigated whether the mechanical stress generated by …
transduction pathways. We investigated whether the mechanical stress generated by …