Risk of bias in studies on prediction models developed using supervised machine learning techniques: systematic review

CLA Navarro, JAA Damen, T Takada, SWJ Nijman… - bmj, 2021 - bmj.com
Objective To assess the methodological quality of studies on prediction models developed
using machine learning techniques across all medical specialties. Design Systematic …

Exercise benefits on Alzheimer's disease: State-of-the-science

PL Valenzuela, A Castillo-García, JS Morales… - Ageing research …, 2020 - Elsevier
Although there is no unanimity, growing evidence supports the value of regular physical
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …

Four distinct trajectories of tau deposition identified in Alzheimer's disease

JW Vogel, AL Young, NP Oxtoby, R Smith… - Nature medicine, 2021 - nature.com
Alzheimer's disease (AD) is characterized by the spread of tau pathology throughout the
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …

Artificial intelligence in brain MRI analysis of Alzheimer's disease over the past 12 years: A systematic review

TO Frizzell, M Glashutter, CC Liu, A Zeng, D Pan… - Ageing Research …, 2022 - Elsevier
Introduction Multiple structural brain changes in Alzheimer's disease (AD) and mild cognitive
impairment (MCI) have been revealed on magnetic resonance imaging (MRI). There is a fast …

A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap

AP Badhwar, GP McFall, S Sapkota, SE Black… - Brain, 2020 - academic.oup.com
Aetiological and clinical heterogeneity is increasingly recognized as a common
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …

Electrochemical biosensor for point-of-care testing of low-abundance biomarkers of neurological diseases

Z Huang, L Zhang, Y Dou, X Liu, S Song… - Analytical …, 2024 - ACS Publications
The neurofilament protein light chain (NEFL) is a potential biomarker of neurodegenerative
diseases, and interleukin-6 (IL-6) is also closely related to neuroinflammation. Especially …

A high-generalizability machine learning framework for predicting the progression of Alzheimer's disease using limited data

C Wang, Y Li, Y Tsuboshita, T Sakurai, T Goto… - NPJ digital …, 2022 - nature.com
Alzheimer's disease is a neurodegenerative disease that imposes a substantial financial
burden on society. A number of machine learning studies have been conducted to predict …

The road to personalized medicine in Alzheimer's disease: The use of artificial intelligence

A Silva-Spínola, I Baldeiras, JP Arrais, I Santana - Biomedicines, 2022 - mdpi.com
Dementia remains an extremely prevalent syndrome among older people and represents a
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …

Subty** of mild cognitive impairment using a deep learning model based on brain atrophy patterns

K Kwak, KS Giovanello, A Bozoki, M Styner… - Cell Reports …, 2021 - cell.com
Trajectories of cognitive decline vary considerably among individuals with mild cognitive
impairment (MCI). To address this heterogeneity, subty** approaches have been …

Improving Alzheimer diagnoses with an interpretable deep learning framework: Including neuropsychiatric symptoms

S Liu, Y Zheng, H Li, M Pan, Z Fang, M Liu, Y Qiao… - Neuroscience, 2023 - Elsevier
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by the
progressive cognitive decline. Among the various clinical symptoms, neuropsychiatric …