Chronic pain exerts an enormous personal and economic burden, affecting more than 30%
of people worldwide according to some studies. Unlike acute pain, which carries survival …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Importance Research into acupuncture and acupressure and their application for cancer
pain has been growing, but the findings have been inconsistent. Objective To evaluate the …

Background: In response to adverse outcomes from prescription opioids, the Centers for
Disease Control and Prevention (CDC) released the Guideline for Prescribing Opioids for …

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Objective To quantify the effects of varying opioid prescribing patterns after surgery on
dependence, overdose, or abuse in an opioid naive population. Design Retrospective …

Abstract The United States opioid epidemic is a nationwide public health crisis. Initially
driven by increased consumption and availability of pharmaceutical opioids, an increasing …

Importance Long-acting opioids increase the risk of unintentional overdose deaths but also
may increase mortality from cardiorespiratory and other causes. Objective To compare all …

Importance Risk of opioid use disorder, overdose, and death from prescription opioids
increases as dosage, duration, and use of extended-release and long-acting formulations …