The attachment of single-celled organisms, namely bacteria and fungi, to abiotic surfaces is
of great interest to both the scientific and medical communities. This is because the …

Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology | Nature
Nanotechnology Skip to main content Thank you for visiting nature.com. You are using a …

We used force-measuring optical tweezers to induce complete mechanical unfolding and
refolding of individual Escherichia coli ribonuclease H (RNase H) molecules. The protein …

Through the study of single molecules it has become possible to explain the function of
many of the complex molecular assemblies found in cells,,,,. The protein titin provides …

Many biologically important macromolecules undergo motions that are essential to their
function. Biophysical techniques can now resolve the motions of single molecules down to …

Cells can sense and transduce a broad range of mechanical forces into distinct sets of
biochemical signals that ultimately regulate cellular processes, including adhesion …

Analyses of genomes show that more than 70% of eukaryotic proteins are composed of
multiple domains. However, most studies of protein folding focus on individual domains and …

Spider capture silk is a natural material that outperforms almost any synthetic material in its
combination of strength and elasticity. The structure of this remarkable material is still largely …

Ubiquitin chains are formed through the action of a set of enzymes that covalently link
ubiquitin either through peptide bonds or through isopeptide bonds between their C …

Experiment and simulation are now conspiring to give atomic-level descriptions of protein
folding relevant to folding, misfolding, trafficking, and degradation in the cell. We are on the …