Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as
proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue …

Simple Summary Ovarian cancer is a lethal disease in women with a 10-year survival rate
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …

Type I interferons (IFNs) are essential innate immune proteins that maintain tissue
homeostasis through tonic expression and can be upregulated to drive antiviral resistance …

STAT3, an oncogene drives tumor growth and is associated with poor prognosis. However,
small molecule-based STAT3 inhibitors were unsuccessful in clinics. Recently, STAT3 …

Papillary thyroid carcinoma contributes to about 80% of the total thyroid cancer cases.
BRAFV600E is a frequently occurring mutation in PTCs. Although several BRAF inhibitors …

NADPH is a cofactor used by reactive oxygen species (ROS) scavenging enzymes to block
ROS produced in cells. Recently, it was shown that in cancer cells, ROS progressively …

IDH1 mutations are frequent and early events in gliomas. Mutant IDH1 produces D-2HG that
causes epigenetic changes by increasing histone and DNA methylations, thereby …

Reprogramming of metabolic genes and subsequent alterations in metabolic phenotypes
occur widely in malignant tumours, including glioblastoma (GBM). FOXM1 is a potent …

Mutations in the metabolic enzymes, IDH1 and IDH2 are frequently found in glioma,
chondrosarcoma, and acute myeloid leukemia. In our previous study, we showed that …

Heterozygous mutations in IDH1 (isocitrate dehydrogenase 1) are found in most grade II and
III brain tumors. A slew of mutant IDH1 inhibitors were identified soon after the discovery of …