Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

Although single-cell RNA sequencing studies have begun to provide compendia of cell
expression profiles,,,,,,,–, it has been difficult to systematically identify and localize all …

The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …

The functions of epithelial tissues are dictated by the types, abundance and distribution of
the differentiated cells they contain. Attempts to restore tissue function after damage require …

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …

The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Lungs are composed of a system of highly branched tubes that bring air into the alveoli,
where gas exchange takes place. The proximal and distal regions of the lung contain …

Life-long reconstitution of a tissue's resident stem cell compartment with engrafted cells has
the potential to durably replenish organ function. Here, we demonstrate the engraftment of …