ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Y Zhao, X Hu, Y Liu, S Dong, Z Wen, W He, S Zhang… - Molecular cancer, 2017 - Springer
Cancer cells are frequently confronted with metabolic stress in tumor microenvironments
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …
The PI3K/AKT pathway and renal cell carcinoma
H Guo, P German, S Bai, S Barnes, W Guo, X Qi… - Journal of genetics and …, 2015 - Elsevier
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling …
pathway components and in more tumor types than any other growth factor signaling …
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but
how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as …
how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as …
Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling
J Han, L Zhang, H Guo, WZ Wysham, DR Roque… - Gynecologic …, 2015 - Elsevier
Objectives Obesity and diabetes are well-known risk factors for the development of
endometrial cancer. A high rate of aerobic glycolysis represents a key mechanism by which …
endometrial cancer. A high rate of aerobic glycolysis represents a key mechanism by which …
Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation
CF Hsieh, CK Liu, CT Lee, LE Yu, JY Wang - Scientific reports, 2019 - nature.com
Diabetes mellitus is associated with an increased risk of Alzheimer's dementia and cognitive
decline. The cause of neurodegeneration in chronic diabetic patients remains unclear …
decline. The cause of neurodegeneration in chronic diabetic patients remains unclear …
The PI3K pathway in B cell metabolism
J Jellusova, RC Rickert - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
B cell growth and proliferation is tightly regulated by signaling through the B cell receptor
and by other membrane bound receptors responding to different cytokines. The PI3K …
and by other membrane bound receptors responding to different cytokines. The PI3K …
Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth
S Marchi, M Corricelli, A Branchini, VAM Vitto… - The EMBO …, 2019 - embopress.org
Although mitochondria play a multifunctional role in cancer progression and Ca2+ signaling
is remodeled in a wide variety of tumors, the underlying mechanisms that link mitochondrial …
is remodeled in a wide variety of tumors, the underlying mechanisms that link mitochondrial …
Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
C Chen, Z Wang, Y Qin - Frontiers in pharmacology, 2022 - frontiersin.org
Cancer cells undergo metabolic adaptations to sustain their growth and proliferation under
several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is …
several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is …
Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling
KA Marijt, M Sluijter, L Blijleven, SH Tolmeijer… - … for immunotherapy of …, 2019 - Springer
Background T-cell mediated immunotherapy brought clinical success for many cancer
patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently …
patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently …
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
AC Klarer, J O'Neal, Y Imbert-Fernandez, A Clem… - Cancer & …, 2014 - Springer
Background Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family
of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) control the conversion …
of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) control the conversion …