In recent decades, the increasing interest in the field of immunotherapy has fostered an
intense investigation of the breast cancer (BC) immune microenvironment. In this context …

Gene-expression profiling has had a considerable impact on our understanding of breast
cancer biology. During the last 15 years, 5 intrinsic molecular subtypes of breast cancer …

ABSTRACT The 14th St Gallen International Breast Cancer Conference (2015) reviewed
substantial new evidence on locoregional and systemic therapies for early breast cancer …

Background The four intrinsic subtypes of breast cancer, defined by differential expression of
50 genes (PAM50), have been shown to be predictive of risk of recurrence and benefit of …

Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized
to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no …

Importance There has been significant recent interest in understanding the utility of
quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic …

Background HER2-positive breast cancer consists of four intrinsic molecular subtypes—
luminal A, luminal B, HER2-enriched, and basal-like—and a normal-like subtype, with the …

Background In our randomised, controlled, phase 3 trial NeOAdjuvant Herceptin (NOAH)
trial in women with HER2-positive locally advanced or inflammatory breast cancer …

Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic
alterations. Often, these changes underlie cancer development, progression, and drug …

Biological changes that occur during metastatic progression of breast cancer are still
incompletely characterized. In this study, we compared intrinsic molecular subtypes and …