Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

The functionalization of C (sp3)− H bonds streamlines chemical synthesis by allowing the
use of simple molecules and providing novel synthetic disconnections. Intensive recent …

Conspectus Enolate alkylation and conjugate addition into an α, β-unsaturated system have
served as long-standing strategic disconnections for the installation of α-or β-substituents on …

Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …

The palladium (II)‐catalyzed C (sp3)− H alkynylation of oligopeptides was developed with
tetrabutylammonium acetate as a key additive. Through molecular design, the acetylene …

Cobaltacycle synthesis via C–H activation has been achieved for the first time, providing key
mechanistic insight into cobalt catalytic chemistry. N-Chloroamides are used as a directing …

We highlight the reported developments of the palladium-catalyzed C–H activation and
functionalization of the inactive/unreactive prochiral C (sp3)–H bonds of aliphatic and …

An efficient method for the synthesis of bicyclic spirodiamine molecules via β-C (sp3)–H
bond activation of aliphatic amides, followed by cyclization with maleimides, has been …

In this study we report the identification of a novel class of ligands for palladium‐catalyzed C
(sp3)− H activation that enables the direct alkynylation of free carboxylic acid substrates. In …

C− C triple bonds are amongst the most versatile functional groups in synthetic chemistry.
Complementary to the Sonogashira coupling the direct metal‐catalyzed alkynylation of C− H …