Bone defect repair caused by trauma, congenital malformation, tumors, infection or systemic
diseases remains the focus of attention in regeneration medicine. Recent advances in …

Background A considerable number of studies has been carried out to develop alloplastic
bone graft materials such as hydroxyapatite (HAP) that mimic the hierarchical structure of …

Barrier membrane-free guided bone regeneration (GBR) with a synthetic scaffold may
resolve the current challenges in vertical bone augmentation. To realize such GBR, we …

The reconstruction of critical-sized segmental bone defects is a key challenge in orthopedics
because of its intractability despite technological advancements. To overcome this …

Although the channel architecture of a scaffold is critical for bone regeneration, little is
known for the channel direction. In this study, four types of carbonate apatite cylindrical …

Successful fracture healing is dependent on an optimal mechanical and biological
environment at the fracture site. Disturbances in fracture healing (non-union) or even critical …

Surgical site infection (SSI) is a severe complication associated with orthopedic bone
reconstruction. For both infection prevention and bone regeneration, the framework surface …

The aging population has rapidly driven the demand for bone regeneration. The pore
structure of a scaffold is a critical factor that affects its mechanical strength and bone …

Scaffolds for bone tissue engineering should have sufficient mechanical properties
comparable with those of the surrounding native bone tissue. Therefore, it is necessary to …

A Voronoi method is a feasible approach for develo** biomimetic trabecular scaffolds.
This study used algorithms based on scaling factors to design Voronoi scaffolds (pore sizes …