Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Epileptic seizures are characterized by periods of hypersynchronous, hyperexcitability within
brain networks. Most seizures involve two stages: an initial tonic phase, followed by a longer …

Neuronal intracellular chloride concentration [Cl–] i is an important determinant of γ-
aminobutyric acid type A (GABAA) receptor (GABAAR)–mediated inhibition and cytoplasmic …

Neuroinflammation represents a dynamic process of defense and protection against the
harmful action of infectious agents or other detrimental stimuli in the central nervous system …

Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The
breakdown in this inhibitory restraint and propagation of seizure activity has been linked to …

In in vitro models of acute brain injury, neuronal death may overwhelm the capacity for
microglial phagocytosis, creating a queue of dying neurons awaiting clearance. Neurons …

mTOR is activated in epilepsy, but the mechanisms of mTOR activation in post-traumatic
epileptogenesis are unknown. It is also not clear whether mTOR inhibition has an anti …

We report the design and application of a Micro Electro Mechanical Systems (MEMs) device
that permits investigators to create arbitrary network topologies. With this device …

Current anti-epileptic medications that boost synaptic inhibition are effective in reducing
several types of epileptic seizure activity. Nevertheless, these drugs can generate significant …