The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …

Metabolomics, an omic science in systems biology, is the global quantitative assessment of
endogenous metabolites within a biological system. Either individually or grouped as a …

Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …

BACKGROUND AND PURPOSE: In a limited number of patients, the level of myo-inositol
(MI), as seen by proton magnetic resonance spectroscopy (HMRS), has been shown to differ …

Despite an increasing application of copper nanoparticles, there is a serious lack of
information concerning their impact on human health and the environment. In this study, the …

High resolution one-and multi-dimensional NMR spectra measured on biological samples
can be extremely complex. For example, for pure proteins in solution, and for biofluids and …

1H NMR spectroscopic and pattern recognition (PR)-based methods were used to
investigate the biochemical variability in urine obtained from control rats and from rats …

The pharmaceutical industry has embraced emerging technologies such as genomics,
proteomics and metabonomics over the past decade with a view to minimizing attrition and …

This article describes the new approach known as metabonomics, a combination of data-
rich analytical chemistry and chemometrics for profiling metabolism in complex systems …

BACKGROUND Metabolomics, the study of all metabolites produced in the body, which
often includes flora and drug metabolites, is the omics approach that can be considered …