Novel hereditary angioedema linked with a heparan sulfate 3-O-sulfotransferase 6 gene mutation
K Bork, K Wulff, BS Möhl, L Steinmüller-Magin… - Journal of Allergy and …, 2021 - Elsevier
Background Hereditary angioedema (HAE) is a potentially fatal disorder resulting in
recurrent attacks of severe swelling. It may be associated with a genetic deficiency of …
recurrent attacks of severe swelling. It may be associated with a genetic deficiency of …
The rebirth of the contact pathway: a new therapeutic target
The rebirth of the contact pathway: a new therapeutic target : Current Opinion in Hematology
The rebirth of the contact pathway: a new therapeutic target : Current Opinion in Hematology …
The rebirth of the contact pathway: a new therapeutic target : Current Opinion in Hematology …
Exploring bradykinin: A common mediator in the pathophysiology of sepsis and atherosclerotic cardiovascular disease
MZ Siti-Zubaidah, HS Harafinova, AN Liba… - Vascular …, 2024 - Elsevier
Sepsis and atherosclerotic cardiovascular disease (ASCVD) are major health challenges
involving complex processes like inflammation, renin-angiotensin system (RAS) …
involving complex processes like inflammation, renin-angiotensin system (RAS) …
[HTML][HTML] First randomized evaluation of safety, pharmacodynamics, and pharmacokinetics of BAY 1831865, an antibody targeting coagulation factor XI and factor XIa …
B Nowotny, D Thomas, S Schwers, S Wiegmann… - Journal of Thrombosis …, 2022 - Elsevier
Background Bleeding is a clinically significant issue with all current anticoagulants. Safer
antithrombotic strategies are required. Objectives To investigate the safety …
antithrombotic strategies are required. Objectives To investigate the safety …
[HTML][HTML] The contact pathway and sepsis
V Raghunathan, J Zilberman‐Rudenko… - Research and Practice …, 2019 - Elsevier
The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely
dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis …
dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis …
Substrates, cofactors, and cellular targets of coagulation factor XIa
Coagulation factor XI (FXI) has increasingly been shown to play an integral role in several
physiologic and pathological processes. FXI is among several zymogens within the blood …
physiologic and pathological processes. FXI is among several zymogens within the blood …
Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery
The contact system is composed of factor XII (FXII), prekallikrein (PK), and cofactor high-
molecular-weight kininogen (HK). The globular C1q receptor (gC1qR) has been shown to …
molecular-weight kininogen (HK). The globular C1q receptor (gC1qR) has been shown to …
[HTML][HTML] Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
Essentials• Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …
Penicillin causes non-allergic anaphylaxis by activating the contact system
Y Gao, Y Han, X Zhang, Q Fei, R Qi, R Hou, R Cai… - Scientific reports, 2020 - nature.com
Immediate hypersensitivity reaction (IHR) can be divided into allergic-and non-allergic-
mediated, while “anaphylaxis” is reserved for severe IHR. Clinically, true penicillin allergy is …
mediated, while “anaphylaxis” is reserved for severe IHR. Clinically, true penicillin allergy is …
A Model of Zymogen Factor XII: Insights into Protease Activation
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to
the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight …
the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight …