Melanoma: from mutations to medicine

H Tsao, L Chin, LA Garraway… - Genes & …, 2012 - genesdev.cshlp.org
Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

Emerging trends in the epidemiology of melanoma

V Nikolaou, AJ Stratigos - British journal of dermatology, 2014 - academic.oup.com
Cutaneous melanoma (CM) is one of the most rapidly growing cancers worldwide, with a
consistent increase in incidence among white populations over the past four decades …

Melanoma genetics

J Read, KAW Wadt, NK Hayward - Journal of medical genetics, 2016 - jmg.bmj.com
Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of develo** melanoma …

[HTML][HTML] Melanoma epidemiology, biology and prognosis

Z Ali, N Yousaf, J Larkin - European Journal of Cancer Supplements, 2013 - Elsevier
Melanoma is a cancer arising from the malignant transformation of melanocytes. These
pigment-producing cells derive embryologically from pluripotent neural crest stem cells …

Biological invasions: a field synopsis, systematic review, and database of the literature

E Lowry, EJ Rollinson, AJ Laybourn… - Ecology and …, 2013 - Wiley Online Library
Species introductions of anthropogenic origins are a major aspect of rapid ecological
change globally. Research on biological invasions has generated a large literature on many …

The genome of the platyfish, **phophorus maculatus, provides insights into evolutionary adaptation and several complex traits

M Schartl, RB Walter, Y Shen, T Garcia, J Catchen… - Nature …, 2013 - nature.com
Several attributes intuitively considered to be typical mammalian features, such as complex
behavior, live birth and malignant disease such as cancer, also appeared several times …

PI3K/Akt-mediated regulation of p53 in cancer

AG Abraham, E O'Neill - Biochemical Society Transactions, 2014 - portlandpress.com
Mutations activating the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway and
inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells …

Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis

PS Linsley, C Speake, E Whalen, D Chaussabel - PloS one, 2014 - journals.plos.org
While immunotherapies are rapidly becoming mainstays of cancer treatment, significant
gaps remain in our understanding of how to optimally target them, alone or in combination …

Genetic variation and gastric cancer risk: a field synopsis and meta-analysis

S Mocellin, D Verdi, KA Pooley, D Nitti - Gut, 2015 - gut.bmj.com
Background Data on genetic susceptibility to sporadic gastric carcinoma have been
published at a growing pace, but to date no comprehensive overview and quantitative …

[HTML][HTML] Obesity and risk of malignant melanoma: a meta-analysis of cohort and case–control studies

TN Sergentanis, AG Antoniadis, HJ Gogas… - European journal of …, 2013 - Elsevier
Although obesity is an established risk factor for several cancer types, its possible role in the
aetiology of malignant melanoma remains unclear. This meta-analysis aims to examine the …