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Melanoma: from mutations to medicine
Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
Emerging trends in the epidemiology of melanoma
V Nikolaou, AJ Stratigos - British journal of dermatology, 2014 - academic.oup.com
Cutaneous melanoma (CM) is one of the most rapidly growing cancers worldwide, with a
consistent increase in incidence among white populations over the past four decades …
consistent increase in incidence among white populations over the past four decades …
Melanoma genetics
Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of develo** melanoma …
positive family history is associated with an increased risk of develo** melanoma …
[HTML][HTML] Melanoma epidemiology, biology and prognosis
Melanoma is a cancer arising from the malignant transformation of melanocytes. These
pigment-producing cells derive embryologically from pluripotent neural crest stem cells …
pigment-producing cells derive embryologically from pluripotent neural crest stem cells …
Biological invasions: a field synopsis, systematic review, and database of the literature
Species introductions of anthropogenic origins are a major aspect of rapid ecological
change globally. Research on biological invasions has generated a large literature on many …
change globally. Research on biological invasions has generated a large literature on many …
The genome of the platyfish, **phophorus maculatus, provides insights into evolutionary adaptation and several complex traits
Several attributes intuitively considered to be typical mammalian features, such as complex
behavior, live birth and malignant disease such as cancer, also appeared several times …
behavior, live birth and malignant disease such as cancer, also appeared several times …
PI3K/Akt-mediated regulation of p53 in cancer
AG Abraham, E O'Neill - Biochemical Society Transactions, 2014 - portlandpress.com
Mutations activating the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway and
inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells …
inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells …
Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis
While immunotherapies are rapidly becoming mainstays of cancer treatment, significant
gaps remain in our understanding of how to optimally target them, alone or in combination …
gaps remain in our understanding of how to optimally target them, alone or in combination …
Genetic variation and gastric cancer risk: a field synopsis and meta-analysis
Background Data on genetic susceptibility to sporadic gastric carcinoma have been
published at a growing pace, but to date no comprehensive overview and quantitative …
published at a growing pace, but to date no comprehensive overview and quantitative …
[HTML][HTML] Obesity and risk of malignant melanoma: a meta-analysis of cohort and case–control studies
Although obesity is an established risk factor for several cancer types, its possible role in the
aetiology of malignant melanoma remains unclear. This meta-analysis aims to examine the …
aetiology of malignant melanoma remains unclear. This meta-analysis aims to examine the …