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Bioactive aurones, indanones, and other hemiindigoid scaffolds: Medicinal chemistry and photopharmacology perspectives
LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …
[HTML][HTML] Aurones: A golden resource for active compounds
Deemed as poorly represented in nature, aurones have been often overlooked by
researchers compared to other members of the flavonoid superfamily. However, over the …
researchers compared to other members of the flavonoid superfamily. However, over the …
Recent advances on synthesis and biological activities of aurones
Aurones are naturally occurring structural isomerides of flavones that have diverse
bioactivities including antiviral, antibacterial, antifungal, anti-inflammatory, antitumor …
bioactivities including antiviral, antibacterial, antifungal, anti-inflammatory, antitumor …
Aurone: A biologically attractive scaffold as anticancer agent
Aurones are very simple, promising anticancer lead molecules containing three rings (A, B
and C). A very slight structural variation in the aurones elicits diverse affinity and specificity …
and C). A very slight structural variation in the aurones elicits diverse affinity and specificity …
Benzofuran as a promising scaffold for the synthesis of novel antimicrobial agents
Introduction The benzofuran moiety constitutes a main component of enormous biologically
active natural and synthetic heterocycles. Such heterocycles have distinctive therapeutic …
active natural and synthetic heterocycles. Such heterocycles have distinctive therapeutic …
Design, synthesis, in-vitro, in-silico and DFT studies of novel functionalized isoxazoles as antibacterial and antioxidant agents
A series of new isoxazolederivatives incorporating the sulfonate ester function has been
synthesized from 2-benzylidenebenzofuran-3 (2 H)-one, known as aurone. The synthesis of …
synthesized from 2-benzylidenebenzofuran-3 (2 H)-one, known as aurone. The synthesis of …
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …
continues to reexamine and mine plant metabolites for novel compounds and to guide …
Design of aurone‐based dual‐state emissive (DSE) fluorophores
The development of dual‐state emissive (DSE) fluorophores, ie organic molecules showing
balanced emission in both solution and as molecular solids, has recently become an …
balanced emission in both solution and as molecular solids, has recently become an …
L-proline-based natural deep eutectic solvents as efficient solvents and catalysts for the ultrasound-assisted synthesis of aurones via knoevenagel condensation
MA Karadendrou, I Kostopoulou, V Kakokefalou… - Catalysts, 2022 - mdpi.com
Aurones are minor flavonoids that possess a wide variety of bioactivity, including
antioxidant, anticancer, and enzyme inhibitory activity. L-proline-based natural deep eutectic …
antioxidant, anticancer, and enzyme inhibitory activity. L-proline-based natural deep eutectic …
[HTML][HTML] Exploring the 2′-hydroxy-chalcone framework for the development of dual antioxidant and soybean lipoxygenase inhibitory agents
I Kostopoulou, A Tzani, NI Polyzos, MA Karadendrou… - Molecules, 2021 - mdpi.com
2′-hydroxy-chalcones are naturally occurring compounds with a wide array of bioactivity. In
an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) …
an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) …