Myocardial architecture, mechanics, and fibrosis in congenital heart disease

S Ghonim, I Voges, PD Gatehouse… - Frontiers in …, 2017 - frontiersin.org
Congenital heart disease (CHD) is the most common category of birth defect, affecting 1% of
the population and requiring cardiovascular surgery in the first months of life in many …

[HTML][HTML] An interactive simulation tool for patient-specific clinical decision support in single-ventricle physiology

T Conover, AM Hlavacek, F Migliavacca, E Kung… - The Journal of Thoracic …, 2018 - Elsevier
Objective Modeling of single-ventricle circulations has yielded important insights into their
unique flow dynamics and physiology. Here we translated a state-of-the-art mathematical …

Reproducing patient-specific hemodynamics in the Blalock–Taussig circulation using a flexible multi-domain simulation framework: applications for optimal shunt …

CJ Arthurs, P Agarwal, AV John, AL Dorfman… - Frontiers in …, 2017 - frontiersin.org
For babies born with hypoplastic left heart syndrome, several open-heart surgeries are
required. During Stage I, a Norwood procedure is performed to construct an appropriate …

Investigation of cerebral hemodynamics during endovascular aspiration: Development of an experimental and numerical setup

CA Luisi, A Amiri, M Büsen, T Sichermann… - Cardiovascular …, 2023 - Springer
Purpose Acute ischemic stroke is a life-threatening emergency caused by an occlusion of a
cerebral artery through a blood clot. Aspiration thrombectomy is an endovascular therapy for …

Numerical investigation of two-phase non-Newtonian blood flow in bifurcate pulmonary arteries with a flow resistant using Eulerian multiphase model

Y Ling, J Tang, H Liu - Chemical Engineering Science, 2021 - Elsevier
In this study, blood flow in bifurcate channels that are pulmonary arteries after a novel
surgery with Blalock–Taussig (BT) shunt and intrapulmonary-artery fenestrated septation is …

Patient-specific multi-scale model analysis of hemodynamics following the hybrid norwood procedure for hypoplastic left heart syndrome: Effects of reverse Blalock …

A Ceballos, R Prather, E Divo, AJ Kassab… - Cardiovascular …, 2019 - Springer
Abstract Introduction The hybrid Norwood (HN) is a relatively new first stage palliative
procedure for neonates with hypoplastic left heart syndrome, in which a sustainable uni …

Precision in Norwood Shunt Sizing: Single Ventricle Reconstruction Trial Public Dataset Analysis

L Raga, H Heydarian, D Winlaw, H Zang… - The Annals of Thoracic …, 2024 - Elsevier
Background Morbidity and mortality after the Norwood procedure remains high. Shunt size
selection is not standardized and the impact of shunt size on outcomes is poorly understood …

[HTML][HTML] Computational fluid dynamics investigation of the novel hybrid comprehensive stage II operation

M Hameed, R Prather, E Divo, A Kassab, D Nykanen… - JTCVS open, 2021 - Elsevier
Background The hybrid comprehensive stage 2 (HCS2) procedure is a novel palliative
operation applicable to a select subset of single ventricle patients with adequate native …

Investigating the hemodynamics of Berlin Heart EXCOR support in Norwood patients across diverse clinical scenarios with computational modeling

V Yuan, F De Gaetano, K Osouli, AL Marsden… - Artificial …, 2023 - Wiley Online Library
Background Infants with single‐ventricle (SV) physiology undergo the 3‐stage Fontan
surgery. Norwood patients, who have completed the first stage, face the highest interstage …

In vitro validation of a multiscale patient-specific Norwood palliation model

T Hang, A Giardini, G Biglino, T Conover… - Asaio Journal, 2016 - journals.lww.com
In Norwood physiology, shunt size and the occurrence of coarctation can affect
hemodynamics significantly. The aim of the study was to validate an in vitro model of the …