Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
De novo genes
Although the majority of annotated new genes in a given genome appear to have arisen
from duplication-related mechanisms, recent studies have shown that genes can also …
from duplication-related mechanisms, recent studies have shown that genes can also …
What can ribo-seq, immunopeptidomics, and proteomics tell us about the noncanonical proteome?
Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …
the human genome and proteome by illuminating thousands of noncanonical sites of …
Selection of a de novo gene that can promote survival of Escherichiacoli by modulating protein homeostasis pathways
Cellular novelty can emerge when non-functional loci become functional genes in a process
termed de novo gene birth. But how proteins with random amino acid sequences …
termed de novo gene birth. But how proteins with random amino acid sequences …
The origins and functions of de novo genes: Against all odds?
CM Weisman - Journal of Molecular Evolution, 2022 - Springer
Abstract “De novo” genes evolve from previously non-genic DNA. This strikes many of us as
remarkable, because it seems extraordinarily unlikely that random sequence would produce …
remarkable, because it seems extraordinarily unlikely that random sequence would produce …
Enzyme function and evolution through the lens of bioinformatics
Enzymes have been shaped by evolution over billions of years to catalyse the chemical
reactions that support life on earth. Dispersed in the literature, or organised in online …
reactions that support life on earth. Dispersed in the literature, or organised in online …
Random, de novo, and conserved proteins: how structure and disorder predictors perform differently
Understanding the emergence and structural characteristics of de novo and random proteins
is crucial for unraveling protein evolution and designing novel enzymes. However …
is crucial for unraveling protein evolution and designing novel enzymes. However …
[HTML][HTML] Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning
Background: De novo protein coding genes emerge from scratch in the non-coding regions
of the genome and have, per definition, no homology to other genes. Therefore, their …
of the genome and have, per definition, no homology to other genes. Therefore, their …
Structural characterization of human de novo protein NCYM and its complex with a newly identified DNA aptamer using atomic force microscopy and small-angle X …
S Yamamoto, F Kono, K Nakatani, M Hirose… - Frontiers in …, 2023 - frontiersin.org
NCYM, a Homininae-specific oncoprotein, is the first de novo gene product experimentally
shown to have oncogenic functions. NCYM stabilizes MYCN and β-catenin via direct binding …
shown to have oncogenic functions. NCYM stabilizes MYCN and β-catenin via direct binding …
[PDF][PDF] Sequence, Structure, and Functional Space of Drosophila De Novo Proteins
L Middendorf, B Ravi Iyengar… - Genome Biology and …, 2024 - academic.oup.com
During de novo emergence, new protein coding genes emerge from previously nongenic
sequences. The de novo proteins they encode are dissimilar in composition and predicted …
sequences. The de novo proteins they encode are dissimilar in composition and predicted …