The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-
translational delivery of proteins to their proper membrane localization and secretory …

Considerable developments have been observed in fragment-based lead/drug discovery
(FBLD/FBDD) recently, with four drugs approved and many others under investigation …

Porphyromonas gingivalis is a Gram-negative, anaerobic oral pathobiont, an etiological
agent of periodontitis and the most commonly studied periodontal bacterium. Multiple low …

Honeybees, essential pollinators for maintaining biodiversity, are experiencing a sharp
population decline, which has become a pressing environmental concern. Among the …

RNA-binding proteins (RBPs) are a major class of proteins that interact with RNAs to change
their fate or function. RBPs and the ribonucleoprotein complexes they constitute are involved …

Small molecules as antibacterial agents have contributed immensely to the growth of
modern medicine over the last several decades. However, the emergence of drug resistance …

Antimicrobial resistance threatens our current standards of care for the treatment and
prevention of infectious disease. Antibiotics that have multiple targets have a lower …

Over the past 30 years, Acinetobacter baumannii has been described as an important
nosocomial pathogen due to frequent ventilator-associated infections. Many biological …

The Gram-negative pathogen, Acinetobacter baumannii, poses a serious threat to human
health due to its role in nosocomial infections that are resistant to treatment with current …

The bacterial signal recognition particle (SRP) receptor, FtsY, participates with the SRP in co-
translation targeting of proteins. Multiple crystal structures of the NG domain of E. coli FtsY …