Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

Adeno-associated viral (AAV) vectors have emerged as crucial tools in advancing gene
therapy for skeletal diseases, offering the potential for sustained expression with low …

Sickle cell disease (SCD) is the most-common monogenic recessive disease in humans,
annually affecting almost 300,000 newborns worldwide, 75% of whom live in Africa …

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized
by progressive disabling heterotopic ossification (HO) at extra-skeletal sites. Here, we …

Background: Inflammation is a major driver of heterotopic ossification (HO), a condition of
abnormal bone growth in a site that is not normally mineralized. Purpose of review: This …

As a class of short non-coding ribonucleic acids (RNAs), microRNAs (miRNA) regulate gene
expression in human cells and are expected to be nucleic acid drugs to regulate and treat a …

Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue
tropism remains an unresolved challenge that limits its full potential despite that the tissue …

Aging can lead to various disorders in organisms and with the escalating impact of
population aging, the incidence of age-related diseases is steadily increasing. As a major …

Fibrodysplasia ossificans progressiva (FOP) is an enigmatic, ultra-rare genetic disorder
characterized by progressive heterotopic ossification, wherein soft connective tissues …

Heterotopic ossification (HO) is a non-physiological bone formation where soft tissue
progenitor cells differentiate into chondrogenic cells. In fibrodysplasia ossificans progressiva …